Nooglutyl – CAS 112193-35-8

Nooglutyl is supplied by Rexar as a chemical reference material for analytical chemistry, compound identification and laboratory-based comparison workflows. This material is intended for controlled research environments requiring verified chemical identity, structural confirmation and consistent reference specifications.

Nooglutyl (CAS 112193-35-8) is available directly through the Rexar webshop and supplied in sealed laboratory packaging for distribution within the EU.

Rexar Technical Compound Datasheet (PDF)

Comprehensive structural overview

Nooglutyl is structurally defined as N-[(5-hydroxy-3-pyridinyl)carbonyl]-L-glutamic acid, combining a substituted pyridine ring with an L-glutamic acid backbone through an amide linkage. The molecule therefore integrates an aromatic heterocycle with a naturally occurring amino acid derivative, resulting in a hybrid structure containing both heteroaromatic and dicarboxylic functional domains.

The pyridine moiety contributes a nitrogen-containing aromatic ring system that exhibits defined electronic distribution and predictable spectroscopic characteristics. Substitution at the 5-position with a hydroxyl group further modifies electron density and hydrogen bonding capacity, which may influence chromatographic retention and solubility behaviour under laboratory conditions.

The glutamic acid segment introduces two carboxylic acid functionalities and a primary amine-derived amide bond. This results in a molecule with multiple ionisable groups, making pH-dependent analytical behaviour a relevant consideration in aqueous systems.

Molecular architecture and functional groups

The molecular formula C₁₀H₁₀N₂O₆ describes a compact but functionally dense structure. Nooglutyl contains:

• A heteroaromatic pyridine ring
• A phenolic hydroxyl group
• An amide linkage
• Two carboxylic acid groups
• Multiple hydrogen bond donor and acceptor sites

This arrangement produces a molecule with amphoteric characteristics. Under controlled laboratory conditions, protonation and deprotonation states may vary depending on pH, influencing solubility and chromatographic retention behaviour.

Stereochemical considerations

The compound incorporates the L-configuration of glutamic acid. Stereochemical integrity may be relevant in analytical workflows that distinguish between enantiomeric or diastereomeric forms. While Nooglutyl itself is defined by its specific stereochemical configuration, analytical confirmation may involve NMR evaluation or chiral chromatographic techniques where applicable.

Registry data and reference identifiers

• Chemical name: N-[(5-Hydroxy-3-pyridinyl)carbonyl]-L-glutamic acid
• Other names: Nooglutil, ONK-10
• IUPAC name: N-[(5-Hydroxy-3-pyridinyl)carbonyl]-L-glutamic acid
• CAS number: 112193-35-8
• Molecular formula: C₁₀H₁₀N₂O₆
• Molecular weight: 254.20 g/mol
• Appearance: White to off-white crystalline powder

Physicochemical characteristics

Nooglutyl is typically encountered as a crystalline solid under standard laboratory storage conditions. Due to the presence of multiple polar functional groups, the compound exhibits hydrophilic tendencies and may demonstrate solubility in aqueous or polar organic solvents depending on pH.

Physicochemical evaluation may include:

• Melting point determination
• Mass spectrometric molecular ion confirmation
• Infrared absorption band analysis
• NMR spectral characterisation
• pH-dependent solubility profiling

Spectroscopic profile

From an analytical perspective, aromatic proton environments of the substituted pyridine ring generate characteristic chemical shifts in proton NMR spectra. The amide carbonyl and carboxylic acid groups may be identified via infrared spectroscopy through distinct carbonyl stretching bands.

Mass spectrometric analysis may confirm molecular weight and fragmentation pathways consistent with cleavage of the amide bond or loss of carboxyl functional groups under controlled ionisation conditions.

Chromatographic behaviour

Due to its polar structure and ionisable groups, Nooglutyl may demonstrate retention patterns influenced by mobile phase composition and pH. Reverse-phase HPLC methods may require optimisation of buffer systems to ensure reproducible peak shape and resolution.

Analytical workflows may evaluate:

• Retention time consistency
• Peak symmetry
• UV absorbance profile
• Stability under analytical conditions

Analytical and laboratory applications

Nooglutyl may be used as a qualitative reference material in analytical workflows, including retention time comparison, spectral confirmation and structural verification under standard laboratory conditions.

• Analytical reference for glutamate derivatives and pyridine carboxamides
• Method development and validation
• Chromatographic and spectroscopic analysis (e.g. HPLC, NMR, UV)
• Comparative profiling and structural integrity assessment under controlled laboratory conditions

Material integrity and batch traceability

Each batch is supplied in sealed laboratory packaging to maintain material stability during storage and transport. Batch identifiers support traceability and internal documentation within professional laboratory systems.

Packaging, availability and traceability

• Sealed laboratory packaging
• Batch-labelled for internal identification
• Available for direct order via the Rexar webshop
• Supplied within the European Union

Handling and storage conditions

• Storage: Store in a cool, dry, dark environment between 8–20 °C.
• Handling: Handle in accordance with standard laboratory safety procedures.
• Personal protection: Use appropriate laboratory protective equipment.
• Shelf life: Up to 24 months when stored correctly.

Reference identifiers

• CAS: 112193-35-8
• Molecular formula: C₁₀H₁₀N₂O₆
• Molecular weight: 254.20 g/mol

Additional public reference

Molecular structure data and selected physicochemical properties can be consulted via the public database: Nooglutyl on PubChem .

Frequently asked technical questions

What is the CAS number of Nooglutyl?
The CAS number of Nooglutyl is 112193-35-8.

What functional groups are present in Nooglutyl?
The compound contains a substituted pyridine ring, phenolic hydroxyl group, amide linkage and two carboxylic acid groups.

Is Nooglutyl supplied as a salt form?
No. This material is supplied as the defined molecular compound corresponding to CAS 112193-35-8.

Is this product intended for human or animal use?
No. This material is supplied exclusively as a laboratory reference compound.

Is Nooglutyl available for shipment within the EU?
Yes. Orders are supplied through the Rexar webshop in sealed laboratory packaging.

Electronic structure and aromatic characteristics

The substituted pyridine ring within Nooglutyl introduces a heteroaromatic system containing a ring nitrogen atom capable of participating in hydrogen bonding and protonation–deprotonation equilibria. The hydroxyl substitution on the aromatic system may influence electron distribution and resonance stabilisation, contributing to defined UV absorption characteristics.

Aromatic heterocycles such as substituted pyridines typically display distinct absorbance maxima in UV-visible spectroscopy due to π–π* transitions. These spectral features may assist in compound identification and purity assessment during analytical workflows.

Acid-base properties and ionisation behaviour

Nooglutyl contains multiple ionisable groups including two carboxylic acid functionalities and a heteroaromatic nitrogen. Under controlled laboratory conditions, protonation states vary depending on pH, potentially influencing solubility, chromatographic retention and electrophoretic mobility.

Buffer selection and pH optimisation are therefore relevant considerations in HPLC or LC-MS method development. Ionisation behaviour may also influence peak symmetry and retention reproducibility.

Solid-state and crystalline characteristics

As a low molecular weight organic compound with multiple hydrogen bonding sites, Nooglutyl may exhibit defined crystalline packing influenced by intermolecular hydrogen bonding networks. Solid-state analysis techniques such as differential scanning calorimetry (DSC) or powder X-ray diffraction (PXRD) may be employed for characterisation where required.

Crystalline stability and moisture sensitivity may vary depending on environmental exposure. Storage under dry, controlled conditions supports long-term material consistency.

Mass spectrometric fragmentation pathways

In mass spectrometric analysis, fragmentation patterns may include cleavage of the amide bond linking the pyridine moiety to the glutamic acid backbone. Loss of carboxyl groups under ionisation conditions may also generate predictable fragment ions useful for structural confirmation.

These fragmentation pathways support qualitative identification and comparative profiling in analytical reference workflows.

Comparative structural classification

Nooglutyl belongs structurally to the broader class of glutamate-derived amide compounds incorporating heteroaromatic substituents. Within chemical registries, such compounds are categorised under substituted amino acid derivatives and pyridine-containing carboxamides.

Structural comparison with related glutamate conjugates may assist in method optimisation when multiple reference materials are analysed within the same laboratory environment.

Analytical method development considerations

During analytical method development, parameters that may require optimisation include mobile phase composition, gradient profiles, buffer strength, ion suppression effects in LC-MS systems and detection wavelength selection in UV analysis.

The presence of both aromatic and carboxylic functional groups allows for multi-modal detection strategies depending on laboratory instrumentation.

Stability and degradation considerations

As with many amino acid derivatives, potential degradation pathways under extreme pH, elevated temperature or prolonged moisture exposure may include hydrolysis of the amide bond or decarboxylation reactions. Routine analytical verification supports long-term stability monitoring in professional storage conditions.

Extended technical FAQ

Does Nooglutyl contain stereochemical configuration?
Yes. The compound incorporates the L-configuration of glutamic acid within its molecular structure.

Is the compound hygroscopic?
Hygroscopic behaviour may depend on environmental humidity. Storage in dry conditions is recommended to preserve material integrity.

Can Nooglutyl be analysed by LC-MS?
Yes. The compound’s molecular mass and functional groups are compatible with LC-MS analysis under standard laboratory conditions.

Are multiple ionisation states possible?
Yes. Due to the presence of carboxylic acid groups and heteroaromatic nitrogen, ionisation states may vary depending on pH.

Disclaimer:
This product is intended for laboratory research use only. It is not intended for human or animal consumption, nor for medical, diagnostic, or therapeutic applications.