es
Cesta
Noopept (CAS 157115-85-0) is supplied by Rexar as a research-grade chemical reference material for analytical chemistry, structural verification and laboratory comparison workflows. This synthetic dipeptide-derived compound is provided exclusively for controlled research environments requiring confirmed chemical identity, reproducible analytical characteristics and consistent documentation standards.
Noopept is available directly through the Rexar webshop and is supplied in sealed laboratory packaging for distribution within the European Union.
Rexar Technical Compound Datasheet (PDF)
Noopept is a synthetic compound structurally derived from a dipeptide framework. The molecule consists of a substituted pyrrolidine core linked via an amide bond to a glycine-derived ester moiety. The structure incorporates both peptide-like and small-molecule characteristics, combining amide functionality, ester linkage and aromatic substitution within a compact molecular architecture.
The molecular formula C17H22N2O4 and molecular weight of 318.37 g/mol reflect a balanced distribution of nitrogen and oxygen-containing functional groups. These heteroatoms significantly influence polarity, hydrogen bonding capacity and chromatographic behaviour under defined laboratory conditions.
Noopept contains a stereogenic centre within the pyrrolidine ring system, designated as the (2S) configuration in its IUPAC nomenclature. Stereochemical definition is relevant for structural confirmation workflows and analytical reproducibility.
Chiral integrity may be evaluated using chiral chromatography or advanced spectroscopic techniques in specialised research settings. Maintenance of stereochemical consistency contributes to reliable reference material performance.
The amide bond exhibits classical resonance stabilisation, resulting in restricted rotation and defined geometry. The ester linkage introduces additional polarity and potential hydrolytic sensitivity under extreme pH conditions, although stability is maintained under recommended storage parameters.
The phenylacetyl group introduces an aromatic ring system that contributes to UV absorbance and characteristic spectroscopic features. Aromatic protons produce identifiable signals in proton NMR spectra, while aliphatic ring and side-chain protons provide complementary structural information.
This dual aromatic–aliphatic composition allows clear differentiation from non-aromatic racetam derivatives during chromatographic or spectroscopic analysis.
Electron density is concentrated around carbonyl oxygen atoms and the amide nitrogen, forming primary hydrogen bond acceptor and donor sites. The ester carbonyl further contributes to the molecule’s dipole moment and intermolecular interaction profile.
In solution, hydrogen bonding interactions with protic solvents may influence solvation dynamics and chromatographic peak behaviour.
The combination of aromatic, amide and ester functionalities results in amphiphilic characteristics. Key analytical properties that may be evaluated include:
Mass spectrometric analysis confirms the molecular ion corresponding to 318.37 g/mol. Fragmentation may occur at the amide bond or ester linkage, generating diagnostic fragments useful for structural confirmation.
The aromatic ring may contribute to stabilised fragment ions under electrospray ionisation conditions, supporting compound identification in LC-MS workflows.
In reversed-phase HPLC systems, retention behaviour is influenced by the aromatic phenyl group and overall hydrophobic surface area. Gradient optimisation may be required to achieve precise separation from structurally related compounds.
Mobile phase composition and pH can affect ester stability and ionisation characteristics, making controlled method parameters important for reproducible results.
The ethyl ester functional group may be susceptible to hydrolysis under strongly acidic or basic conditions. Under neutral laboratory storage conditions, structural integrity is maintained.
For analytical applications, freshly prepared solutions and controlled solvent environments support consistent analytical performance.
Noopept is typically encountered as a white crystalline powder. Crystal lattice stability may be supported by hydrogen bonding interactions between amide and carbonyl groups.
Controlled storage in a dry, dark environment assists in maintaining consistent physical appearance and analytical reproducibility.
Noopept | CAS: 157115-85-0 | Molecular formula: C17H22N2O4 | Molecular weight: 318.37 g/mol.
Noopept may serve as a qualitative reference material in analytical laboratories performing compound verification, retention time comparison and spectroscopic confirmation. It may be incorporated into comparative profiling workflows involving peptide-derived or small-molecule analogues.
What is the CAS number of Noopept?
The CAS number of Noopept is 157115-85-0.
In which form is Noopept supplied?
This product is supplied as a white crystalline powder in sealed laboratory packaging.
Is this product intended for human or animal use?
No. This material is supplied exclusively as a laboratory reference compound.
Is Noopept available for shipment within the EU?
Yes. Orders are supplied through the Rexar webshop in sealed laboratory packaging.
Noopept exhibits restricted rotational freedom across its amide linkage due to classical resonance stabilisation. The partial double-bond character of the amide bond enforces near-planarity around the carbonyl–nitrogen axis, reducing conformational entropy in solution.
The pyrrolidine ring adopts defined envelope conformations that may influence spatial orientation of the phenylacetyl substituent. Computational modelling of torsional angles across the amide and ester bonds may provide insight into three-dimensional geometry under different solvent environments.
The molecule contains multiple hydrogen bond acceptor sites, including two carbonyl oxygens and one amide nitrogen. Depending on solvent polarity, intermolecular hydrogen bonding interactions may influence solubility and chromatographic peak shape.
In protic solvents, hydrogen bonding interactions can stabilise solvated conformations, whereas in aprotic media dipole–dipole interactions dominate.
The phenylacetyl moiety contributes π-electron density and aromatic resonance stabilisation. Aromatic systems typically exhibit characteristic UV absorbance profiles, which may assist in detection during chromatographic analysis using UV detectors.
Substitution patterns within the aromatic ring may influence electron distribution across the amide linkage through inductive and resonance effects.
While stable under recommended storage conditions, ester-containing compounds may theoretically undergo hydrolysis under strongly acidic or basic environments. Analytical protocols typically employ neutral or buffered systems to preserve structural integrity.
Controlled solvent selection and avoidance of prolonged exposure to extreme pH conditions support reproducible analytical measurements.
Compared to classical racetam derivatives lacking ester functionality, Noopept presents increased structural complexity due to its dipeptide-inspired architecture. The combination of aromatic substitution and ester linkage distinguishes it within small molecule reference collections.
In analytical comparison workflows, differentiation from structurally related lactam derivatives may be achieved through retention time modelling, UV absorbance patterns and mass spectrometric fragmentation behaviour.
Under electrospray ionisation, protonated molecular ions may fragment at the amide bond or ester linkage. Cleavage at these positions generates structurally informative fragment ions.
The aromatic phenyl group may stabilise certain fragment ions via resonance, resulting in characteristic mass spectral signatures useful for confirmation.
High-resolution mass spectrometry (HRMS) permits exact mass determination consistent with the molecular formula C17H22N2O4. Isotopic distribution patterns align with natural abundance of carbon, hydrogen, nitrogen and oxygen.
Exact mass confirmation supports compound verification in research-grade analytical workflows.
Retention behaviour in reversed-phase chromatography may be influenced by the hydrophobic aromatic domain and overall molecular polarity. Adjustment of gradient slope and organic solvent percentage may improve separation efficiency.
Buffer selection and pH optimisation may further refine peak symmetry and resolution when analysing alongside related peptide-derived compounds.
In crystalline form, intermolecular hydrogen bonding between amide and carbonyl groups may stabilise lattice structure. Aromatic stacking interactions are less dominant but may contribute to packing efficiency depending on crystal arrangement.
Consistent crystalline morphology supports reliable dissolution behaviour and reproducible analytical preparation.
Differential scanning calorimetry may reveal defined melting transitions indicative of solid-state purity. Thermal stability under standard laboratory storage conditions contributes to long-term analytical consistency.
Proper storage in sealed laboratory packaging minimises environmental influence and preserves structural integrity.
This product is intended for laboratory research use only. It is not intended for human or animal consumption, nor for medical, diagnostic, or therapeutic applications.
| Intended use: | Laboratory research and analytical reference purposes only |
| Application area: | Analytical chemistry, reference comparison and method development |
| End user: | Professional users in controlled research environments |
| Regulatory classification: | Chemical reference material |
